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Metastatic HER2-Positive Breast Cancer Resource Center

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Phase I study and cell-free DNA analysis of T-DM1 and metronomic temozolomide for secondary prevention of HER2-positive breast cancer brain metastases 

Last Updated: Thursday, April 13, 2023

Data from a phase 1 trial of 12 patients with HER2+ breast cancer with previously treated brain metastases suggests that combination therapy with T-DM1 and metronomic temozolomide has low-grade toxicity and may be effective in the secondary prevention of HER2+ brain metastases.

Clinical Cancer Research
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