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Gastrointestinal Stromal Tumor Resource Center

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Ripretinib versus sunitinib in gastrointestinal stromal tumor: ctDNA biomarker analysis of the phase 3 INTRIGUE trial

Last Updated: Monday, June 24, 2024

INTRIGUE was an open-label, phase 3 study in adult patients with advanced GIST who had disease progression on or intolerance to imatinib and were randomized to once-daily ripretinib 150 mg or sunitinib 50 mg. In the primary analysis, progression-free survival with ripretinib was not superior to sunitinib. The exploratory analysis suggested ctDNA sequencing may improve the prediction of the efficacy of single-drug therapies and support further evaluation of ripretinib in patients with KIT exon 11 + 17/18 mutations. 

Nature Medicine
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