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Transformation to diffuse large B-cell lymphoma and its impact on survival in patients with marginal zone lymphoma: A population-based study

Last Updated: Wednesday, December 6, 2023

Data from a population-based study of patients with marginal zone lymphoma (MZL) demonstrated that those with splenic disease had a higher 10-year cumulative incidence rate of transformation to DLBCL (5.8% [95% CI: 4.6%-7.1%]) than those with extranodal (1.5% [95% CI: 1.3%-1.8%]) or nodal disease (2.7% [95% CI: 2.3%-3.2%]). Patients with DLBCL transformed from MZL had a shorter overall survival compared with patients with matched de novo DLBCL (5-year rate, 46.1% [95% CI: 40.9%-51.9%] vs 56.6% [95% CI: 51.9%-61.8%]; P < .001).  

  

International Journal of Cancer
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