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Overcoming barriers to referral for chimeric antigen receptor T cell therapy in patients with relapsed/refractory diffuse large B cell lymphoma

Last Updated: Friday, October 6, 2023

This review article highlights the proven efficacy of CD19-directed CAR T-cell therapy among patients with relapsed/refractory DLBCL, as well the myriad barriers preventing some eligible patients from receiving this novel treatment—including cost of therapy, patient hesitancy, and timely patient selection—and recommendations to overcome these barriers.

Transplantation and Cellular Therapy
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News & Literature Highlights

2025 American Society of Clinical Oncology Annual Meeting Abstract

Efficacy and safety of polatuzumab vedotin plus rituximab, cyclophosphamide, doxorubicin and prednisone for previously untreated diffuse large B-cell lymphoma: A real-world, multi-center, retrospective cohort study

2025 American Society of Clinical Oncology Annual Meeting Abstract

Glofitamab plus gemcitabine and oxaliplatin (Glofit-GemOx) in patients (pts) with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL): 2-year (yr) follow-up of STARGLO

2025 American Society of Clinical Oncology Annual Meeting Abstract

Impact of CAR T cell therapy product in the clinical outcome of patients with relapsed/refractory diffuse large B-cell lymphoma

2025 Transplantation & Cellular Therapy Meetings Abstract

Tandem CD20-CD19-directed non-cryopreserved CAR T cells - zamtocabtagene autoleucel (Zamto-Cel) in patients with relapsed/refractory diffuse large B cell lymphoma - interim results from a phase 2 pivotal study (DALY II USA)

Nature Cancer

Odronextamab monotherapy in patients with relapsed/refractory diffuse large B cell lymphoma: primary efficacy and safety analysis in phase 2 ELM-2 trial

HemaSphere

Age‐ and gender‐specific molecular characteristics of diffuse large B‐cell lymphoma: Results from clinical trials of the DSHNHL/GLA

Journal of Clinical Oncology

Brentuximab vedotin combination for relapsed diffuse large B-cell lymphoma

OncLive

ctDNA testing joins NCCN Guidelines for MRD assessment in DLBCL

The Lancet

Glofitamab plus gemcitabine and oxaliplatin (GemOx) versus rituximab-GemOx for relapsed or refractory diffuse large B-cell lymphoma (STARGLO): a global phase 3, randomised, open-label trial

European Society for Medical Oncology (ESMO) Congress 2024 Abstract

806MO - Phase Ib study of NT-I7 (efineptakin alfa), a long-acting IL-7, post-CD19-directed CAR T cell therapy in diffuse large B-cell lymphoma (DLBCL)

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