Large B cell lymphoma microenvironment archetype profiles
Last Updated: Monday, August 11, 2025
Using single-nucleus multimode sequencing, researchers analyzed DLBCL tumor cells and identified three lymphoma microenvironment archetype profiles. After applying the data to the ZUMA-7 clinical trial, which compared CAR-T cell therapy to standard chemotherapy, they further discovered that patients with one of these three profiles are those most likely to benefit from CAR T-cell therapy.
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