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DLBCL Resource Center

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Glofitamab plus chemotherapy meets OS end point in R/R DLBCL

Last Updated: Tuesday, May 7, 2024

The phase 3 STARGLO study recently met its primary endpoint, as treatment with the bispecific CD20-directed CD3 T-cell engager glofitamab plus gemcitabine and oxaliplatin led to a statistically significant improvement in overall survival (OS) vs rituximab plus gemcitabine and oxaliplatin in patients with relapsed/refractory DLBCL who had received at least 1 prior line of therapy and were not eligible for autologous stem cell transplant. 

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News & Literature Highlights

2025 American Society of Clinical Oncology Annual Meeting Abstract

Efficacy and safety of polatuzumab vedotin plus rituximab, cyclophosphamide, doxorubicin and prednisone for previously untreated diffuse large B-cell lymphoma: A real-world, multi-center, retrospective cohort study

2025 American Society of Clinical Oncology Annual Meeting Abstract

Glofitamab plus gemcitabine and oxaliplatin (Glofit-GemOx) in patients (pts) with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL): 2-year (yr) follow-up of STARGLO

2025 American Society of Clinical Oncology Annual Meeting Abstract

Impact of CAR T cell therapy product in the clinical outcome of patients with relapsed/refractory diffuse large B-cell lymphoma

2025 Transplantation & Cellular Therapy Meetings Abstract

Tandem CD20-CD19-directed non-cryopreserved CAR T cells - zamtocabtagene autoleucel (Zamto-Cel) in patients with relapsed/refractory diffuse large B cell lymphoma - interim results from a phase 2 pivotal study (DALY II USA)

Nature Cancer

Odronextamab monotherapy in patients with relapsed/refractory diffuse large B cell lymphoma: primary efficacy and safety analysis in phase 2 ELM-2 trial

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Age‐ and gender‐specific molecular characteristics of diffuse large B‐cell lymphoma: Results from clinical trials of the DSHNHL/GLA

Journal of Clinical Oncology

Brentuximab vedotin combination for relapsed diffuse large B-cell lymphoma

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ctDNA testing joins NCCN Guidelines for MRD assessment in DLBCL

The Lancet

Glofitamab plus gemcitabine and oxaliplatin (GemOx) versus rituximab-GemOx for relapsed or refractory diffuse large B-cell lymphoma (STARGLO): a global phase 3, randomised, open-label trial

European Society for Medical Oncology (ESMO) Congress 2024 Abstract

806MO - Phase Ib study of NT-I7 (efineptakin alfa), a long-acting IL-7, post-CD19-directed CAR T cell therapy in diffuse large B-cell lymphoma (DLBCL)

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