Comprehensive geriatric assessment as a useful tool in predicting adverse events in elderly patients with diffuse large B-cell lymphoma

Data from a multicenter, prospective study of elderly patients with newly diagnosed DLBCL who underwent baseline comprehensive geriatric assessment demonstrated that an impairment of instrumental activities of daily living was independently associated with grade 3/4 leukopenia (OR 0.63; 95% CI, 0.43-0.92; P = 0.017) and anemia (OR 0.67; 95% CI, 0.50-0.90; P = 0.008). In addition, presence of a comorbidity was associated with grade 3/4 nonhematological toxicity (OR 2.17; 95% CI, 1.37-3.43; P = 0.001).