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Chronic Lymphocytic Leukemia Resource Center

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Computational flow cytometry provides accurate assessment of measurable residual disease in chronic lymphocytic leukaemia

Last Updated: Wednesday, July 12, 2023

Clustering algorithms may address user bias and expertise limitations in performance of multiparameter flow cytometry. Using FlowSOM, 456 samples from two different laboratories were assessed. Computational analysis showed high concordance with expert analysis and even detected disease in a small number of atypical CLL cases that went undetected by expert analysis. 

British Journal of Haematology
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