Recent Advances and Discoveries in the Mechanisms and Functions of CAR T Cells

Last Updated: Tuesday, October 19, 2021

This review discusses the major advances and changes made over the past 3 years to the understanding of CAR T-cell efficacy and safety, including mechanisms of toxicity and resistance as well as novel engineering and pharmaceutical interventions to overcome these challenges.

Nature Reviews Cancer

Cure

Novel CAR-T Cell Therapy Produces Early and Deep Responses in Certain Patients With Multiple Myeloma

Transplantation and Cellular Therapy

ASTCT, CIBMTR, and ESBMT Clinical Practice Recommendations for Transplantation and Cellular Therapies

Journal of Blood Medicine

Assessing and Management of Neurotoxicity After CAR-T Therapy in Diffuse Large B-Cell Lymphoma

Biology of Blood and Marrow Transplantation

Chimeric Antigen Receptor T Cell Therapy During the COVID-19 Pandemic

Expert Review of Anti-Infective Therapy

CAR-T Cell Therapy and Infection: A Review

Blood Advances

Comparison of 2-Year Outcomes With CAR T Cells (ZUMA-1) Versus Salvage Chemotherapy in Refractory Large B-Cell Lymphoma

The ASCO Post

Early-Phase Study Explores CAR T-Cell Therapy for Relapsed or Refractory B-Cell Lymphoma

Nature Reviews Clinical Oncology

Engineering Strategies to Overcome the Current Roadblocks in CAR T Cell Therapy

Journal of Clinical Oncology

Anti-CD30 CAR-T Cell Therapy in Relapsed and Refractory Hodgkin Lymphoma

Journal of the Advanced Practitioner in Oncology

CAR T-Cell Therapy: Adverse Events and Management

CAR T-Cell Therapy Resource Center