Next Generation Chimeric Antigen Receptor T Cells: Safety Strategies to Overcome Toxicity
Last Updated: Tuesday, March 15, 2022
Researchers have developed a number of safety strategies of CAR-T cells, including suicide genes, synthetic Notch receptor, on-switch CAR, combinatorial target-antigen recognition, bispecific T cell engager and inhibitory CAR. This review summarizes the preclinical studies and clinical trials of the safety strategies of CAR-T cells and their respective strengths and weaknesses.
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