Development of ALL-Hematotox (ALL-HT): Predicting post CAR T-cell hematotoxicity in B-cell acute lymphoblastic leukemia

Last Updated: Tuesday, March 25, 2025

Researchers developed the ALL-Hematotoxicity score, which refines an existing predictive model of post CAR T-cell cytopenias to be applicable to B-cell acute lymphoblastic leukemia. The ALL-Hematotoxicity score was associated with severe prolonged neutropenia. It appropriately predicted patients who had more cumulative days of neutropenia, fewer rates of complete response, and shorter median overall survival.

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