Clinical features, pathophysiology, and management of acute myelopathy following CAR T-cell therapy

Last Updated: Friday, October 10, 2025

As CAR T-cell therapy use expands, rare neurologic complications such as acute myelopathy are being increasingly reported. Researchers examine the clinical features, pathophysiology, and management strategies for acute myelitis following CAR T-cell therapy, drawing on insights from reported cases in the literature.

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Clinical features, pathophysiology, and management of acute myelopathy following CAR T-cell therapy

Future Oncology

Establishing a successful outpatient CAR T-cell program with cilta-cel: Real-world experience from an expert roundtable

Blood

Clinical features, pathophysiology, and management of acute myelopathy following CAR T-cell therapy

EBioMedicine

Advancements and challenges in developing in vivo CAR T cell therapies for cancer treatment

Diagnostics (Basel)

CAR-T cell therapy in ovarian cancer: Where are we now?

U.S. Food and Drug Administration

FDA eliminates risk evaluation and mitigation strategies (REMS) for autologous chimeric antigen receptor CAR T-cell immunotherapies

Journal for ImmunoTherapy of Cancer

rhIL-7-hyFc, a long-acting interleukin-7, improves efficacy of CAR T-cell therapy in solid tumors

Nature Reviews Immunology

In vivo CAR engineering for immunotherapy

Seminars in Arthritis and Rheumatism

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BCMA-directed CAR T-cell therapy in patients with multiple myeloma and CNS involvement

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