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CAR T-Cell Therapy Resource Center

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CAR T-Cell Therapy as Second-Line Treatment in Large B-Cell Lymphomas

Last Updated: Tuesday, March 15, 2022

About 30% to 40% of patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL) experience relapse, and 10% are refractory to the regimen of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone. Most relapses occur during the first 2 years. This article reviews what was learned from the randomized BELINDA, TRANSFORM, and ZUMA-7 trials.

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