Boosting CAR-T cell therapy through vaccine synergy

Last Updated: Tuesday, April 22, 2025

A clinical review of various vaccine modalities (including mRNA, peptide, viral vector, and dendritic cell-based vaccines) in solid tumors. The authors discuss crucial considerations for optimizing vaccine dosing, scheduling, and delivery to maximize CAR T synergy.

Trends in Pharmacological Sciences

Oncogene

Preclinical application of a CD155 targeting chimeric antigen receptor T cell therapy for digestive system cancers

Critical Reviews in Oncology/Hematology

Chimeric antigen receptor T cell immunotherapy for gynecological malignancies

International Immunopharmacology

The paths toward immunotherapy of esophageal cancer: An overview of clinical trials

Trends in Pharmacological Sciences

Boosting CAR-T cell therapy through vaccine synergy

Nature Medicine

Long-term outcomes of GD2-directed CAR-T cell therapy in patients with neuroblastoma

Blood Advances

Access barriers to anti-CD19+ CART therapy for NHL across a community transplant and cellular therapy network

Blood

Development of ALL-Hematotox (ALL-HT): Predicting post CAR T-cell hematotoxicity in B-cell acute lymphoblastic leukemia

Science Advances

Development of an antigen-based approach to noninvasively image CAR T cells in real time and as a predictive tool

JAMA Network Open

Cardiovascular events after chimeric antigen receptor T-cell therapy for advanced hematologic malignant neoplasms: A meta-analysis

Blood Advances

Outcome of patients with large B-cell lymphoma treated with tafasitamab plus lenalidomide either before or after CAR T-cell therapy

CAR T-Cell Therapy Resource Center

Boosting CAR-T cell therapy through vaccine synergy

Oncogene

Preclinical application of a CD155 targeting chimeric antigen receptor T cell therapy for digestive system cancers

Critical Reviews in Oncology/Hematology

Chimeric antigen receptor T cell immunotherapy for gynecological malignancies

International Immunopharmacology

The paths toward immunotherapy of esophageal cancer: An overview of clinical trials

Trends in Pharmacological Sciences

Boosting CAR-T cell therapy through vaccine synergy

Nature Medicine

Long-term outcomes of GD2-directed CAR-T cell therapy in patients with neuroblastoma

Blood Advances

Access barriers to anti-CD19+ CART therapy for NHL across a community transplant and cellular therapy network

Blood

Development of ALL-Hematotox (ALL-HT): Predicting post CAR T-cell hematotoxicity in B-cell acute lymphoblastic leukemia

Science Advances

Development of an antigen-based approach to noninvasively image CAR T cells in real time and as a predictive tool

JAMA Network Open

Cardiovascular events after chimeric antigen receptor T-cell therapy for advanced hematologic malignant neoplasms: A meta-analysis

Blood Advances

Outcome of patients with large B-cell lymphoma treated with tafasitamab plus lenalidomide either before or after CAR T-cell therapy

Transverse Myelitis With Paraplegia: An Atypical Manifestation of Neurotoxicity Following CAR T-Cell Therapy

CAR T-cell Infusion in an Outpatient Setting: An Ideal Option for Selected Patients When Available

B-Cell Aplasia, Hypogammaglobulinemia Can Result in Serious, Life-Threatening Infections

Fast Facts #12: BCMA Targets