Biallelic Loss of BCMA as a Resistance Mechanism to CAR T Cell Therapy in a Patient With Multiple Myeloma

Last Updated: Monday, November 15, 2021

BCMA targeting chimeric antigen receptor (CAR) T cell therapy has shown deep and durable responses in multiple myeloma. However, relapse following therapy is frequently observed, and mechanisms of resistance remain ill-defined. The authors suggest the need for careful detection of BCMA gene alterations in multiple myeloma cells from relapse following CAR T cell therapy.

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