ATRA works synergistically with the γ-secretase inhibitor crenigacestat to augment BCMA on multiple myeloma and the efficacy of BCMA-CAR T-cells

Last Updated: Monday, November 21, 2022

Researchers successfully used all-trans retinoic acid (ATRA) to augment B-cell maturation antigen (BCMA) to sustain BCMA expression on multiple myeloma cells and increase BCMA-CAR T-cell efficacy in pre-clinical models.

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