Assessment of Pretreatment and Posttreatment Evolution of Neurofilament Light Chain Levels in Patients Who Develop Immune Effector Cell–Associated Neurotoxicity Syndrome

Researchers connect elevated preinfusion levels of plasma neurofilament light chain (NfL) with the development of immune effector cell–associated neurotoxicity syndrome (ICANS), suggesting that early screening for pre-existing neurologic injury should be considered prior to CAR T-cell therapy administration and that these pre-existing neurologic injuries could be a predictor for ICANS post-therapy.