Approved CAR-T therapies have reproducible efficacy and safety in clinical practice

Last Updated: Wednesday, September 18, 2024

Researchers compared clinical trial data for six U.S. Food and Drug Administration–approved CAR-T therapies with real-world data that is more representative of diverse populations. They concluded that the real-world data was comparable to the clinical trial outcomes that had led to those therapies’ approval.

Human Vaccines & Immunotherapeutics

Blood

CAR T cells vs bispecific antibody as third- or later-line large B-cell lymphoma therapy: A meta-analysis

Blood

Optimizing the post-CAR T monitoring period for axicabtagene ciloleucel, tisagenlecleucel, and lisocabtagene maraleucel

The Lancet

Afamitresgene autoleucel for advanced synovial sarcoma and myxoid round cell liposarcoma (SPEARHEAD-1): An international, open-label, phase 2 trial

Human Vaccines & Immunotherapeutics

Approved CAR-T therapies have reproducible efficacy and safety in clinical practice

New England Journal of Medicine Evidence

CD19 CAR T-cell therapy in autoimmune disease–A case series with follow-up

New England Journal of Medicine Evidence

CAR T-cell immunotherapy in minority patients with lymphoma

Blood Cancer Journal

Autologous transplant vs. CAR-T therapy in patients with DLBCL treated while in complete remission

The ASCO Post

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Cure

Novel CAR-T Cell Therapy Produces Early and Deep Responses in Certain Patients With Multiple Myeloma

Transplantation and Cellular Therapy

ASTCT, CIBMTR, and ESBMT Clinical Practice Recommendations for Transplantation and Cellular Therapies

CAR T-Cell Therapy Resource Center

Approved CAR-T therapies have reproducible efficacy and safety in clinical practice

Blood

CAR T cells vs bispecific antibody as third- or later-line large B-cell lymphoma therapy: A meta-analysis

Blood

Optimizing the post-CAR T monitoring period for axicabtagene ciloleucel, tisagenlecleucel, and lisocabtagene maraleucel

The Lancet

Afamitresgene autoleucel for advanced synovial sarcoma and myxoid round cell liposarcoma (SPEARHEAD-1): An international, open-label, phase 2 trial

Human Vaccines & Immunotherapeutics

Approved CAR-T therapies have reproducible efficacy and safety in clinical practice

New England Journal of Medicine Evidence

CD19 CAR T-cell therapy in autoimmune disease–A case series with follow-up

New England Journal of Medicine Evidence

CAR T-cell immunotherapy in minority patients with lymphoma

Blood Cancer Journal

Autologous transplant vs. CAR-T therapy in patients with DLBCL treated while in complete remission

The ASCO Post

Novel CAR T-cell therapy under study in relapsed or refractory non-Hodgkin lymphoma

Cure

Novel CAR-T Cell Therapy Produces Early and Deep Responses in Certain Patients With Multiple Myeloma

Transplantation and Cellular Therapy

ASTCT, CIBMTR, and ESBMT Clinical Practice Recommendations for Transplantation and Cellular Therapies

CAR T-cell Infusion in an Outpatient Setting: An Ideal Option for Selected Patients When Available

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