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Long-term outcomes of adjuvant denosumab in breast cancer: Fracture reduction and survival results from 3,425 patients in the randomised, double-blind, placebo-controlled ABCSG-18 trial

Last Updated: Monday, June 27, 2022

Long-term outcomes from the phase 3 ABCSG-18 trial of 3,425 postmenopausal patients with early HR+ breast cancer on aromatase inhibitors (AI) show that adjuvant denosumab every six months during AI therapy is safe and reduces treatment-induced clinical fractures.

ASCO Annual Meeting 2022
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News & Literature Highlights

Cells

Breast Cancer with Bone Metastasis: Molecular Insights and Clinical Management

Current Osteoporosis Reports

Updates in Management of Bone Metastatic Disease in Primary Solid Tumors with Systemic Therapies

JAMA Network Open

Association of Concomitant Bone Resorption Inhibitors With Overall Survival Among Patients With Metastatic Castration-Resistant Prostate Cancer and Bone Metastases Receiving Abiraterone Acetate With Prednisone as First-Line Therapy

Journal of the National Comprehensive Cancer Network

Bone Metastases, Skeletal-Related Events, and Survival in Patients With Metastatic Non–Small Cell Lung Cancer Treated With Immune Checkpoint Inhibitors

Annals of Pharmacotherapy

Impact of Extended-Interval Versus Standard Dosing of Zoledronic Acid on Skeletal Events in Non–Small-Cell Lung Cancer and Small-Cell Lung Cancer Patients With Bone Metastases

JAMA Open Network

Description of Major Osteoporotic Fractures in Women With Invasive Breast Cancer Who Received Endocrine Therapy

JAMA Open Network

Evaluation of Frequency of Administration of Intravenous Bisphosphonate and Recurrent Skeletal-Related Events in Patients With Multiple Myeloma

Journal of Bone Oncology

Bone Metastases From Urothelial Carcinoma. The Dark Side of the Moon

Metabolism

Effect of antiresorptive therapy on aromatase inhibitor induced bone loss in postmenopausal women with early-stage breast cancer: A systematic review and meta-analysis of randomized controlled trials

Journal of Clinical Oncology

Use of adjuvant bisphosphonates and other bone-modifying agents in breast cancer: ASCO-OH (CCO) guideline update

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