Landscape and Clonal Dominance of Co-occurring Genomic Alterations in Non–Small-Cell Lung Cancer Harboring MET Exon 14 Skipping

This study evaluated the mutational profile and co-occurring genetic alteration landscape of non–small-cell lung cancer harboring MET exon 14 skipping (METex14) and the clonality relationship between the METex14 and co-occurring mutations inferred from the variant allele frequency. The authors found that METex14 can act as a primary oncogenic driver or resistance mechanism, suggesting that appropriate treatment choices can be potentially guided by co-occurring alterations.