Biomarker Testing for Patients With Advanced Non–Small Cell Lung Cancer: Real-World Issues and Tough Choices

This review discusses the major guidelines recommending biomarker testing in NSCLC, as well the logistical challenges to applying these guidelines to patients with NSCLC both in the United States and worldwide. The techniques commonly used for biomarker testing are discussed, both for tissue- and blood-based biomarkers. Finally, the authors discuss the challenge of interpreting the results of biomarker testing and using these results to guide treatment decisions.