T-cell acute lymphoblastic leukemia: Subtype prevalence, clinical outcome, and emerging targeted treatments

This review article synthesizes genomic landscape studies of T-ALL, a high-risk hematological disease. It details the current understanding of subtype classification using immunophenotyping and cytogenetics, with a focus on ETP-ALL and KMT2A rearrangements. The article also explores emerging genomic subtypes identified by next-generation sequencing and discusses potential targeted treatments based on these classifications.