Promising drugs targeting specific mechanisms of deregulation in T cell lineage acute lymphoblastic leukemia

This review article highlights the urgent need for novel targeted therapies for T-cell acute lymphoblastic leukemia (T-ALL), particularly in adults and relapsed cases. It discusses promising therapeutic agents targeting specific deregulation mechanisms in T-ALL, including oncogene overexpression, signaling pathway deregulation, epigenetic mechanisms, and apoptosis. The article outlines various investigational drugs and approaches aimed at improving outcomes for this aggressive malignancy.