Lineage switch of adult B-cell acute lymphoblastic leukaemia to acute myeloid leukaemia following B-cell-directed therapy

This is a rare medical case where a 79-year-old male with refractory B-cell acute lymphoblastic leukemia experienced a lineage switch to acute myeloid leukemia following treatment with B-cell targeted therapies, specifically blinatumomab and inotuzumab ozogamicin. The authors highlight the potential complication of lineage transformation in patients receiving these otherwise effective treatments for B-cell malignancies. They emphasize the importance of timely recognition of this phenomenon to guide appropriate clinical management, as the patient in the case unfortunately died. The article also provides context through references to other studies on similar lineage switches and the efficacy of the mentioned B-cell therapies.