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Acute Lymphoblastic Leukemia Resource Center

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Daratumumab-induced acute angle closure glaucoma: bone marrow transplantation as a possible risk factor and atropinization as a potential solution

Last Updated: Tuesday, July 22, 2025

In this case study, a 29-year-old female with recurrent T-cell acute lymphoblastic leukemia developed acute angle closure glaucoma after a daratumumab infusion, attributed to ciliochoroidal effusion. Her history of bone marrow transplantation and head-neck radiotherapy were identified as potential risk factors. The condition was successfully managed with topical medications, and atropine premedication prevented recurrence during subsequent infusions. 

BMC Ophthalmology
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