Classification and risk stratification in T-lineage acute lymphoblastic leukemia

This journal article discusses challenges in T-lineage ALL (T-ALL) risk stratification compared to B-lineage ALL, despite overall improved ALL cure rates. While age, CNS involvement, and MRD response are validated prognostic factors, immunophenotype is less consistently linked to outcome. Recent large-scale genomic profiling shows potential, identifying genetic subtypes associated with outcome independently of MRD.