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Acute Lymphoblastic Leukemia Resource Center

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CD22-targeted chimeric antigen receptor-modified T cells for children and adults with relapse of B-cell acute lymphoblastic leukemia after CD19-directed immunotherapy

Last Updated: Wednesday, April 23, 2025

This study investigated CART22-65s, a novel CD22-targeted CAR T-cell therapy, for children and adults with relapsed B-ALL after CD19 therapy. In 19 infused patients, the complete remission rate was 74%. The therapy demonstrated a favorable safety profile, suggesting its potential for treating this highly refractory leukemia.

Journal for Immunotherapy of Cancer
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